Buoyant Bubbles in a Cooling Intracluster Medium I. Hydrodynamic Bubbles

Over the past several years, numerous examples of X-ray cavities coincident with radio sources have been observed in so-called "cool core" clusters of galaxies. Motivated by these observations, we explore the evolution and the effect of cavities on a cooling intracluster medium (ICM) numerically, adding relevant physics step by step. In this paper we present a first set of hydrodynamical, high resolution (1024^3 effective grid elements), three-dimensional simulations, together with two-dimensional test cases. The simulations follow the evolution of radio cavities, modeled as bubbles filled by relativistic plasma, in the cluster atmosphere while the ICM is subject to cooling. We find that the bubble rise retards the development of a cooling flow by inducing motions in the ICM which repeatedly displace the material in the core. Even bubbles initially set significantly far from the cluster center affect the cooling flow, although much later than the beginning of the simulation. The effect is, however, modest: the cooling time is increased by at most only 25%. As expected, the overall evolution of pure hydrodynamic bubbles is at odds with observations, showing that some additional physics has to be considered in order to match the data.Comment: 12 pages, 14 figures, accepted for publication in A&

A statistical procedure for testing financial contagion

The analysis of the relationships among financial markets and the identification of financial contagion episodes are relatively recent in the economic analysis and have experienced a rapid development in the last decade, coinciding with the occurrence of relevant financial crises which had effects that spread outside the geographical areas where they originally started. The increasing interest in this topic has lead to the definition of different tests for detecting the existence of financial contagion (Corsetti et al., 2001; Forbes and Rigobon, 2001; Dungey et al., 2004; Allen and Gale, 2005; Rodriguez, 2007; Krishnamurthy, 2009; Sugihara, 2010). However, conclusions on both theoretical and statistical analyses of financial contagion are far from unique. The changes in the international dynamics of returns, which in the last decades has been characterized by increases in both volatilities and asset price synchronicities in different countries, have raised even further the scientific interest in this topic. In this paper, we propose a new methodology for the evaluation of contagion based on the extent of disequilibria in financial dynamics and, in this framework, we define an innovative test for the detection of contagion which specifically identifies the disequilibrium originated by the international transmission of financial crises and their relationships with the behaviours of market participants. Disequilibria exogenously generated by the spread of the effects of a crisis beyond the dynamic process describing endogenous amplification of volatility from one country to other countries are attributed to contagion phenomena. In this framework, contagion effects are separated from the endogenous transmission processes which have their genesis in both the pricing process system and the investor\u2019s behaviours and which are responsible for the amplification of cross-market financial interdependence. In this paper, we discuss the theoretical framework underlying our approach and define a new econometric model for evaluating contagion among countries

Oxidative Molecular Mechanisms Underlying Liver Diseases: From Systems Biology to the Personalized Medicine

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HEPPA-II model-measurement intercomparison project: EPP indirect effects during the dynamically perturbed NH winter 2008-2009

Funke, B. et. al..--This work is distributed under the Creative Commons Attribution 3.0 License.We compare simulations from three high-top (with upper lid above 120 km) and five medium-top (with upper lid around 80 km) atmospheric models with observations of odd nitrogen (NOx D NO+NO2), temperature, and carbon monoxide from seven satellite instruments (ACE-FTS on SciSat, GOMOS, MIPAS, and SCIAMACHY on Envisat, MLS on Aura, SABER on TIMED, and SMR on Odin) during the Northern Hemisphere (NH) polar winter 2008/2009. The models included in the comparison are the 3-D chemistry transport model 3dCTM, the ECHAM5/MESSy Atmospheric Chemistry (EMAC) model, FinROSE, the Hamburg Model of the Neutral and Ionized Atmosphere (HAMMO-NIA), the Karlsruhe Simulation Model of the Middle Atmosphere (KASIMA), the modelling tools for SOlar Climate Ozone Links studies (SOCOL and CAO-SOCOL), and the Whole Atmosphere Community Climate Model (WACCM4). The comparison focuses on the energetic particle precipitation (EPP) indirect effect, that is, the polar winter descent of NOx largely produced by EPP in the mesosphere and lower thermosphere. A particular emphasis is given to the impact of the sudden stratospheric warming (SSW) in January 2009 and the subsequent elevated stratopause (ES) event associated with enhanced descent of mesospheric air. The chemistry climate model simulations have been nudged toward reanalysis data in the troposphere and stratosphere while being unconstrained above. An odd nitrogen upper boundary condition obtained from MIPAS observations has further been applied to medium-top models. Most models provide a good representation of the mesospheric tracer descent in general, and the EPP indirect effect in particular, during the unperturbed (pre-SSW) period of the NH winter 2008/2009. The observed NOx descent into the lower mesosphere and stratosphere is generally reproduced within 20 %. Larger discrepancies of a few model simulations could be traced back either to the impact of the models' gravity wave drag scheme on the polar wintertime meridional circulation or to a combination of prescribed NOx mixing ratio at the uppermost model layer and low vertical resolution. In March-April, after the ES event, however, modelled mesospheric and stratospheric NOx distributions deviate significantly from the observations. The too-fast and early downward propagation of the NO x tongue, encountered in most simulations, coincides with a temperature high bias in the lower mesosphere (0.2-0.05 hPa), likely caused by an overestimation of descent velocities. In contrast, upper-mesospheric temperatures (at 0.05-0.001 hPa) are generally underestimated by the high-top models after the onset of the ES event, being indicative for too-slow descent and hence too-low NOx fluxes. As a consequence, the magnitude of the simulated NOx tongue is generally underestimated by these models. Descending NOx amounts simulated with mediumtop models are on average closer to the observations but show a large spread of up to several hundred percent. This is primarily attributed to the different vertical model domains in which the NOx upper boundary condition is applied. In general, the intercomparison demonstrates the ability of state-of- the-art atmospheric models to reproduce the EPP indirect effect in dynamically and geomagnetically quiescent NH winter conditions. The encountered differences between observed and simulated NOx, CO, and temperature distributions during the perturbed phase of the 2009 NH winter, however, emphasize the need for model improvements in the dynamical representation of elevated stratopause events in order to allow for a better description of the EPP indirect effect under these particular conditions.This work has been conducted in the frame of the WCRP/ SPARC SOLARIS-HEPPA activity. The IAA team was supported by the Spanish MCINN under grant ESP2014-54362-P and EC FEDER funds. The MPI-MET team was supported by the Max Planck Gesellschaft (MPG), and computational resources were made available by Deutsches Klimarechenzentrum (DKRZ) through support from Bundesministerium fur Bildung und Forschung (BMBF). The FMI team was supported by the Academy of Finland through the projects 276926 (SECTIC: Sun-Earth Connection Through Ion Chemistry), 258165, and 265005 (CLASP: Climate and Solar Particle Forcing). CAO team was supported by the Russian Science Foundation under grant 15-17-10024. SOCOL team was funded by Swiss National Science Foundation (SNSF) grants 200021-149182 (SILA), 200020-163206 (SIMA), and CRSII2-147659 (FUPSOL-II). S. Bender, M. Sinnhuber, and H. Nieder (all KIT) gratefully acknowledge funding by the Helmholtz Association of German Research Centres (HGF), grant VH-NG-624. NCAR is sponsored by the National Science Foundation (NSF). Computing resources for WACCM simulations were provided by the Climate Simulation Laboratory at NCAR's Computational and Information Systems Laboratory, sponsored by the NSF and other agencies. Work at the Jet Propulsion Laboratory, California Institute of Technology, was carried out under a contract with the National Aeronautics and Space Administration. The Atmospheric Chemistry Experiment (ACE), also known as SciSat, is a Canadian-led mission mainly supported by the Canadian Space Agency. Odin is a Swedish-led satellite project funded jointly by Sweden (SNSB), Canada (CSA), Finland (TEKES), and France (CNES) and is part of European Space Agency's (ESA) third-party mission program. We thank two anonymous reviewers for helpful suggestions that led to improvements in the quality of the present work.Peer reviewe

Treatment of squamous cell carcinoma of the anal canal (SCCA): A new era?

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Effects of compost-bedded pack barn on circulating cortisol and beta-endorphins in dairy cows: A case study

SIMPLE SUMMARY: Management and housing conditions have been reported to significantly affect the health and welfare of livestock species. Therefore, the adoption of novel, alternative housing systems (such as the compost-bedded pack barn, developed in the USA) requires extensive research to assess the implications for animal welfare. From a general point of view, animal welfare is typically assessed by means of animal-based (such as blood biochemical markers) and resource-based (such as management practices) indicators. Based on such considerations, the present study evaluated the fluctuation of circulating cortisol and beta-endorphins in dairy cows housed in a conventional freestall barn (FB) and in the alternative compost-bedded pack barn (CB). The results obtained suggest that the CB housing system did not elicit significant changes in either blood cortisol or beta-endorphins. ABSTRACT: The up-to-date literature suggests that the compost-bedded pack barn housing system is capable of remarkably improving productive and reproductive performance, as well as health status and welfare, in dairy cattle. However, there is currently limited knowledge available on the endocrine and biochemical changes in animals housed in such alternative systems. Therefore, this study aimed to measure blood cortisol (COR) and beta-endorphins (BE) in 22 two-year-old primiparae Fleckvieh cows, who were randomly allotted to the following two different housing systems: CB (n = 11) and FB (n = 11). Blood samples were collected at the beginning of the experiment (T0) and every two months thereafter (T1, T2, and T3). The COR and BE were measured through an immunoenzymatic kit. With the only exception being T0, no differences were observed over time between the two groups, neither for COR nor for BE. However, the blood cortisol levels of the CB cows decreased over time, while a T1 peak was identified in the FB group. On the contrary, both the housing systems displayed numerically higher BE at T3 than at the other experimental times. Therefore, the overall data suggest that the compost-bedded pack barn did not significantly affect the studied parameters. Accordingly, cow welfare should be assessed using a wider panel of animal-based indicators

INCREASE OF REPORTS OF SUSPECTED ADVERSE DRUG REACTIONS IN ONCOLOGY

Objective: The information of safety of antineoplastic agents derives solely from clinical studies that have a number of limitations, such as the number of patients enrolled, selected case studies, follow-up of short duration; therefore, it is not possible to identify the complete profile of safety and possible side effects of the drugs under study. ADRs monitoring and reporting programmes aim to identifying and quantifying the risks associated with the use of drugs provided in a hospital setting. The main objectives of this study were to evaluate the ADRs that occurred during hospitalization for chemotherapy in 7 cancer centers, and to facilitate the development of a monitoring system of pharmacovigilance. Methods: An observational study was conducted in 7 cancer centers in the Emilia Romagna region over a period of 2 years, from January 2012 to January 2014. This study was based on an analysis of ADRs reported. Several parameters were utilised in the data evaluation, including drug and reaction characteristics. Results: From January 2012 to January 2014 No. 884 ADRs were included in National Network of pharmacovigilance. The highest ADR rate (57.4%) was found in the adult females with a mean age of 62. The oncology drug most frequently reported were taxanes and platinum derivates. Conclusion: The results obtained will contribute to the development of strategies for the pharmacovigilance service in 7 cancer centers, which will improve the quality of ADR reporting and ensure safer oncology drug use